Fig. 8
From: Chemogenetic modulation of sensory neurons reveals their regulating role in melanoma progression
available at TCGA and curated by Liu et al. (2018) [85]. We stratified patients in two groups, alive or dead, based on a 5-year interval of their tumor diagnosis. B Interactions among genes related to sensory neurons. C Gene signature using sensory neurons-related genes. High expression of these genes (lower patient scores) is associated with a better overall survival of SKCM patients (patients were stratified based on their median Reboot score). Overall survival of patients showing expression of sensory neurons-related genes. More negative scores are associated with higher gene expression. D Expression of SNC10A (Nav1.8) in SKCM samples. Only patients presenting tumors expressing SNC10A were used. E We evaluated the survival probability of patients with melanoma based on their tumor transcriptome. Patients were stratified based on lower/upper quartiles of SCN10A expression values. Overall survival of SKCM patients based on the level of expression of SCN10A. High expression of SCN10A (Nav1.8) correlates with best outcomes in patients with melanoma
Overexpression of genes related to sensory nerves is associated with Skin Cutaneous Melanomas (SKCM) patients improved survival. A Biological Processes of genes overexpressed in Skin Cutaneous Melanomas (SKCM) samples from alive patients versus dead patients. Patients were stratified (alive or dead) based on their vital status in a 5-year interval of their tumor diagnosis (clinical data