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Fig. 10 | Acta Neuropathologica Communications

Fig. 10

From: Chemogenetic modulation of sensory neurons reveals their regulating role in melanoma progression

Fig. 10

Increase in sensory neurons activity leads to increase in intra-tumoral calcitonin gene-related peptide (CGRP). CGRP concentration was measured in tumor samples from Nav1.8-Cre + /hM4Di + and Nav1.8-Cre-/hM4Di + animals (A) and from Nav1.8-Cre + /hM3Dq + and Nav1.8-Cre-/hM3Dq + mice (B). (C) Schematic representation of the association between intra-tumoral concentration of CGRP and tumor size. (n = 5). Data are shown as mean ± SEM

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