Fig. 5

Tauopathy in SCA34. a and b The subthalamic nucleus showing frequent glial fibrillary tangles (arrows) stained with anti-four-repeat tau antibody. Magnified view (b) from the rectangular area in a showing some of the tangles that resemble a tuft-shaped astrocyte (arrow). C A tuft-shaped astrocyte exhibiting argyrophilia on Gallyas silver impregnation in the subthalamic nucleus. d Coiled bodies (arrows) in the subthalamic nucleus stained with the anti-phosphorylated tau antibody, AT8. e A tuft-shaped astrocyte (arrow) in the prefrontal cortex exhibiting argyrophilia on Gallyas silver impregnation. f A tuft-shaped astrocyte in the putamen stained with anti-four-repeat tau antibody. g Glial fibrillary tangles akin to a tuft-shaped astrocyte (arrow) and thread (arrowhead) in the external segment of the globus pallidus, stained with anti-four-repeat tau antibody. h Glial fibrillary tangles in the frontal cortex stained with anti-phosphorylated tau antibody AT8. i Pretangle (arrow) and neurofibrillary tangle (arrowhead) in the substantia nigra pars compacta stained with anti-phosphorylated tau antibody AT8. j The superior colliculus in the midbrain showing frequent glial fibrillary tangles stained with anti-four-repeat tau. k The intraaxial oculomotor nerve partly stained with anti-four-repeat tau antibody in the midbrain (arrowheads). L Few amyloid plaques stained with anti-amyloid antibody in the insular cortex (magnified view of a plaque in inset). Scale Bar = 250 μm (a and k), 100 μm (h and l), 50 μm (b, c, e, f, g, and i), 25 μm (D and inset in L)