Fig. 4

Electron microscopic observation of white matter abnormalities in an autopsy case with SCA34. a, b, c, d, e, and f, transmission electron microscopy of the corpus callosum. a Vacuoles (asterisks) associated with discontinuous and degenerated myelin, which ran nearby (large and small arrows, respectively), are shown. b A ballooned cytoplasmic space (asterisk) and nucleus are at the outermost space of the oligodendroglial cytoplasm. Arrows indicate deformed myelin. Myelin digestion is shown (arrowhead). c An enlarged view from the same site as B showing disrupted myelin fibers (arrows). d Deformed and disrupted myelin (arrows) accompanying cytoplasmic digestion of myelin (arrowheads) is shown. e and f Loose membrane structures, which likely reflect disrupted myelin, in swollen oligodendrocytes, can be observed (arrowheads). Scale bar = 10 μm (e and f), 4 μm (a and b), 2 μm (c and d)