Fig. 17

Perivascular inflammation in the brain of a blast-exposed animal. Panel a shows a brain region with patches of clustered activated microglia (Iba1⁺, red) next to a vascularized region in between the deep cerebral white matter, choroid plexus and hippocampal fimbria. Insert in a shows higher magnification of a 0.56 µm optical section of the area indicated by arrow. Note the tortuous vessel (arrow). Panel b denotes higher magnification of an artery (identified by * in panel a) with perivascular activated microglia (Iba1⁺, red). Panels c, d show GFAP⁺ intracellular material (green) in perivascular activated microglia (Iba1, red; GFAP, green). Scale bar, 200 µm a; 10 µm b–d