Table 1 Summary of clinical information
Group and Case |  | Sex | GA at birth (weeks+ days) | Postnatal age | PMA at death (weeks+ days) | Birth weight (g) | Clinical context | Infection | Neuropathology |
|---|---|---|---|---|---|---|---|---|---|
Control | Â | Â | Â | Â | Â | Â | Â | Â | Â |
1 |  | M | 25 + 3 | 21 h 7 m | 25 + 3 | 820 | Ass IUGR (twin) | None | Edematous brain with transtentorial herniation of the unci, white matter patchy astrocytosis |
2 |  | M | 23 + 6 | 9 h 51 m | 23 + 6 | 520 | Ass IUGR (twin) | None | Leptomeninges congested with focal hemorrhages, drop out of neurons |
3 |  | M | 26 + 2 | 43 h | 26 + 3 | 511.4 | TTF (triplet), Ass IUGR, pulmonary hemorrhage | None | None |
4 |  | F | 24 + 1 | 4 h 40 m | 24 + 1 | 660 | Oligohydramnios, extreme prematurity, congestive heart failure | AAAFI | None |
5 |  | M | 23 + 4 | IUD/Stillbirth | 23 + 4 | 610 |  | AAAFI | None |
6 |  | M | 28 + 1 |  < 1 h | 28 + 1 | 1308.4 | Oligohydramnios, lung hypoplasia, congestive heart failure | None | None |
7 |  | M | 22 + 0 | TOP | 22 + 0 | 401.2 | Anhydramnios, renal agenesis | None | None |
WMI | Â | Â | Â | Â | Â | Â | Â | Â | Â |
8 |  | M | 24 + 0 | 5w 1d 8 h 25 m | 29 + 1 | 1010 | Retroplacental hemorrhage | AAAFI, necrotizing enterocolitis | PVMWI, patchy WM gliosis, oedema, laminar necrosis, and neuron loss (HI) |
9 |  | M | 29 + 3 | 11 h 17 m | 29 + 3 | 1630 | TTF, hydrops fetalis | AAAFI | PVWMI, patchy reactive astrocytosis, drop out of neurons |
10 |  | M | 26 + 5 | 1d 7 h 52 m | 26 + 6 | 641.4 | Ass IUGR (twin), oligohydramnios, congestive heart failure | None | PVWMI, cerebellar hemorrhages, oedema, white matter gliosis |
11 |  | M | 24 + 6 | 16d 19 h 10 m | 27 + 0 | 715.4 | PPROM, acute necrotizing pneumonia | AAAFI | PVWMI, focal neuron loss (HI), drop out of neurons, oedema |
12 |  | M | 26 + 6 | 2d 20 h 46 m | 27 + 1 | 807.6 | TTF | None | Oedema, degenerating neurons, perivascular hemorrhages, neuron loss, apoptotic neurons, PVL (parietal) |
13 |  | F | 27 + 5 | 22d | 30 + 6 | 1440 | Placental hemorrhage, congestive heart failure with edematous | None | Extensive PVL (on MRI), mildly dilated ventricles, drop out of neurons, oedema |
14 |  | F | 27 + 0 | 7d | 28 + 0 | 858.6 | IUGR, congestive heart failure | Necrotizing enterocolitis | Oedema, focal neuronal loss (HI), patchy gliosis in PVWM, PVL (on MRI) right IVH (grade II) – on cranial US |
GMH | Grade | Â | Â | Â | Â | Â | Â | Â | Â |
15 | II | M | 22 + 0 | NND | 22 + 0 | 476 | Congestive heart failure | AAAFI/ Chorio-amnionitis | IVH/GMH, oedema, astrocytosis in white matter of dentate, focal neuronal loss in BG |
16 | I | M | 27 + 5 | 10d 11 h 28 m | 29 + 1 | 940 | Congestive heart failure | AAAFI | Bilateral GMH/IVH (in situ) |
17 | III | M | 24 + 0 | 4w 6d 19 h 12 m | 28 + 6 | 596 | Acute pneumonia, heart failure | AAAFI | Multiple GMH with focal rupture, oedema, patchy astrocytosis, some neuronal loss |
18 | I | F | 26 + 2 | 18d | 28 + 6 | 1126.8 | Ass IUGR, congestive heart failure | Necrotizing enterocolitis | Focal GMH, hemorrhage of right cerebellum WM gliosis |
19 | III | M | 24 + 6 | 53d | 32 + 3 | 1637 | Congestive heart failure | CMV (mild) | GMH, patchy WM gliosis, focal neuronal loss (HI), mild ventriculomegaly |
20 | II | M | 22 + 5 | 4 h 9 m | 22 + 5 | 530 | Mild retroplacental hemorrhage | AAAFI | GMH, oedema |
21 | IV | F | 24 + 1 | 2d 3 h 37 m | 24 + 3 | 460 | Prematurity, congestive heart failure, Ass IUGR | None | GMH, oedema |