Fig. 6

Intraneuronal neurofibrillary tangle and neuropil threads in AD-inoculated animals. AT8-positive neurofibrillary tangle in AD brain inoculed in mouse lemurs were detected after staining with AT8 (a-b), an antibody detecting phosphorylation of S422 (c), and another one targeting phosphorylation of T212 and S214 (AT100) (d). Neuropil threads were revealed after staining with AT8 (c), anti-pS422 antibody (f), AT100 (g), and Gallyas staining (h). Scale bars: 20 µm