Fig. 4

Overview of Aβ and tau pathology spreading throughout the brains of mouse lemurs inoculated with AD brain extracts. Three-dimensional rendering of Aβ and tau pathologies in mouse lemur brains using a three-level semi-quantitative scale (no lesions/intermediate/high lesion load). (a, c-f) Aβ pathology involved almost all cortical regions, except for the entorhinal cortex. The hippocampus was also Aβ-positive. (b, g-j) High levels of tau lesions were reported at the inoculated sites (posterior cingulate cortex, area 7) as well as in juxtaposing regions such as the area 5. Distant regions such as the area 20 also displayed high tau pathology. The hippocampus, entorhinal cortex, and other cortical areas displayed intermediate tau lesion loads. The red arrows indicate the needle tracts. Numbers represent Brodmann areas as reported in the mouse lemur brain by (Le Gros Clark, 1931). AC: anterior cingulate cortex, EC: entorhinal cortex, F: antero-medial frontal cortex, Fs: superior frontal cortex, H: hippocampus, PA: peri-amygdalar cortex, PC: posterior cingulate cortex