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Fig. 12 | Acta Neuropathologica Communications

Fig. 12

From: Transmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate

Fig. 12

Progressive cerebral atrophy induced by AD brain inoculation. Statistical heatmaps of t-values depicting regions in which grey matter volume decreased in AD-inoculated animals compared with Ctrl-inoculated ones (voxel-based morphometry, FDR-corrected p < 0.05; voxel threshold extent k = 10). To increase statistical power, AD1 and AD2-inoculated animals were grouped within a unique AD group. Longitudinal follow-up revealed a slight atrophy in the inoculated posterior cingulate region at 4 mpi (a). No intergroup difference in brain volume was observed between 4 and 9 mpi (b). Grey matter loss however extended to several other regions by 15 mpi (c), without further progressing afterwards until 21 mpi (d). Lateral (e) and dorsal (f) three-dimensional representations showing clusters of atrophied areas. The red arrow and crosses indicate the injection needle tract. 1–3: cerebral cortex areas 1–3, 4: cerebral cortex area 4, 5: cerebral cortex area 5, 6: cerebral cortex area 6, 7: cerebral cortex area 7, 17–18: cerebral cortex areas 17–18, AC: anterior cingulate cortex, BF: basal forebrain, Cd: caudate nucleus, Cl: claustrum, EC: entorhinal cortex, F: antero-medial frontal cortex, Fs: superior frontal cortex, H: hippocampus, Ins: insular cortex (areas 13–16), P: putamen, PA: peri-amygdalar cortex, PC: posterior cingulate cortex, RS: retrosplenial cortex, S: septum, Th: median thalamus [22]

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