Fig. 7
From: TNF-mediated neuroinflammation is linked to neuronal necroptosis in Alzheimer's disease hippocampus
Altered expression of ESCRT III components in the AD hippocampus. a Analysis of mRNA levels of the Vps24, and Vps4b genes in the hippocampus grey matter in AD cases (n = 30) and controls (n = 14). b Representative western blots of CHMP2A, VPS24, CHMP2B, and VPS4B. Full blots are shown in Additional file 6: Fig. 6. c Quantification of CHMP2A, VPS24, CHMP2B, and VPS4B protein levels in AD (n = 20) and control cases (n = 10), normalized to GAPDH. Data are represented as mean ± SEM, **p < 0.01. d Representative immunofluorescence image of Chmp2A (green, top row), Chmp2B (green, second row), Vps24 (green, third row), and Vps4B (green, bottom row) with pMLKL (red) and DAPI + cell nuclei (blue) in the CA1 neurons of AD cases (scale bar = 20 µm)