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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: TNF-mediated neuroinflammation is linked to neuronal necroptosis in Alzheimer's disease hippocampus

Fig. 4

Association of pMLKL with inflammatory markers in AD. a Representative IHC and quantification of HLA-DR positive microglia in control (n = 9) and AD (n = 15) brain sections (scale bar = 100 µm). Data are represented as mean ± SEM, **p < 0.01. b Representative IHC showing CD8 + T cells (brown) in the control (left, n = 9) versus AD (right, n = 20) tissues (scale bar = 100 µm). c Representative image showing pMLKL + neurons (black arrows) in close proximity to HLA-DR + microglia (scale bar = 20 µm), along with correlation analysis between mean HLA-DR intensity and pMLKL + neuron density (r = 0.66, p = 0.0026). d Representative image showing pMLKL + neurons (black arrows) in close proximity to CD8 + T cells (red arrows) (scale bar = 20 µm), along with correlation analysis between CD8 + T cell density and pMLKL + neuron density (r = 0.74, p = 0.0003). Correlation analysis by Spearman comparison

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