Case # number | Clinical diagnosis | Age at death (yr) | Sex | Post-mortem Delay (h) | Fixation time (days) | CERAD | Braak & Braak AD stage | Thal phase | ApoE status | TREM2 variant | Total number of Aβ plaques counted/analyzed ROIs | Total number of pSer8-Aβ plaques counted/analyzed ROIs | Total nmAβ intracellular deposits counted/analyzed ROIs | Total pSer8-Aβ intracellular deposits counted/analyzed ROIs |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
#1 | Dementia (rapidly progressive; without further specification) | 75 | M | 24 | n.i | C | 6 | 5 | E3/E4 | R62H (G > A) | 13,053 | 2286 | 2871 | 1663 |
#2 | Dementia of the Alzheimer type | 78 | F | 21 | 15 | C | 6 | 5 | E3/E4 | R62H (G > A) | 14,125 | 2270 | 2616 | 1496 |
#3 | Dementia (without further specification) | 81 | F | 11–35 | 613 | C | 5 | 5 | E3/E4 | R62H (G > A) | 17,147 | - | 2764 | 2740 |
#4 | Frontotemporal dementia (FTD) | 77 | M | 5 | 25 | C | 5 | 5 | E3/E4 | R62H (G > A) | 15,782 | 4894 | 4415 | 3825 |
#5 | Dementia (without further specification) | 86 | M | 16–40 | 156 | C | 5 | 4 | E3/E4 | R62H (G > A) | 14,296 | 1984 | 3731 | 3675 |
#6 | Frontotemporal dementia (FTD) | 77 | M | 26 | 297 | C | 5 | 4 | E3/E4 | R62C (C > T) | 14,432 | 1857 | 3832 | 2190 |
#7 | Dementia of the Alzheimer type | 81 | F | 60 | 39 | C | 6 | n.i | E3/E4 | None | 9384 | 2057 | 3304 | 1052 |
#13 | Dementia, probably of the Alzheimer type | 82 | M | 15 | 104 | C | 6 | 5 | E3/E4 | None | 9816 | 2759 | 1850 | 1841 |
#14 | Dementia (without further specification) | 85 | M | 27 | 27 | C | 6 | 5 | E3/E4 | None | 9892 | 2386 | 2157 | 1021 |
#15 | Dementia (without further specification) | 85 | M | 49 | 136 | C | 6 | 5 | E3/E4 | None | 16,160 | 4104 | 2404 | 2834 |
#16 | Dementia (without further specification) | 88 | F | 9 | 76 | C | 4 | 5 | E3/E4 | None | 14,698 | 3894 | 2891 | 1224 |
#17 | Dementia of the Alzheimer type | 75 | M | 3–13 | 141 | C | 5 | 5 | E3/E4 | None | 8681 | 2256 | 2295 | 837 |