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Table 2 Demographic and clinical characteristics of the TREM2 coding variants and control (CV) groups. n.i.- no information, ROI- Region of interest. Case#3, with highest fixation time, was omitted for the plaque count and size quantification as it was difficult to define boundaries of extracellular plaques stained with 1E4E11 (pSer8-Aβ) antibody

From: TREM2 modulates differential deposition of modified and non-modified Aβ species in extracellular plaques and intraneuronal deposits

Case # number Clinical diagnosis Age at death (yr) Sex Post-mortem Delay (h) Fixation time (days) CERAD Braak & Braak AD stage Thal phase ApoE status TREM2 variant Total number of Aβ plaques counted/analyzed ROIs Total number of pSer8-Aβ plaques counted/analyzed ROIs Total nmAβ intracellular deposits counted/analyzed ROIs Total pSer8-Aβ intracellular deposits counted/analyzed ROIs
#1 Dementia (rapidly progressive; without further specification) 75 M 24 n.i C 6 5 E3/E4 R62H (G > A) 13,053 2286 2871 1663
#2 Dementia of the Alzheimer type 78 F 21 15 C 6 5 E3/E4 R62H (G > A) 14,125 2270 2616 1496
#3 Dementia (without further specification) 81 F 11–35 613 C 5 5 E3/E4 R62H (G > A) 17,147 - 2764 2740
#4 Frontotemporal dementia (FTD) 77 M 5 25 C 5 5 E3/E4 R62H (G > A) 15,782 4894 4415 3825
#5 Dementia (without further specification) 86 M 16–40 156 C 5 4 E3/E4 R62H (G > A) 14,296 1984 3731 3675
#6 Frontotemporal dementia (FTD) 77 M 26 297 C 5 4 E3/E4 R62C (C > T) 14,432 1857 3832 2190
#7 Dementia of the Alzheimer type 81 F 60 39 C 6 n.i E3/E4 None 9384 2057 3304 1052
#13 Dementia, probably of the Alzheimer type 82 M 15 104 C 6 5 E3/E4 None 9816 2759 1850 1841
#14 Dementia (without further specification) 85 M 27 27 C 6 5 E3/E4 None 9892 2386 2157 1021
#15 Dementia (without further specification) 85 M 49 136 C 6 5 E3/E4 None 16,160 4104 2404 2834
#16 Dementia (without further specification) 88 F 9 76 C 4 5 E3/E4 None 14,698 3894 2891 1224
#17 Dementia of the Alzheimer type 75 M 3–13 141 C 5 5 E3/E4 None 8681 2256 2295 837