The association of Lewy bodies with limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes and their role in cognition and Alzheimer’s dementia in older persons

Table 4 Relation of Lewy bodies and LATE-NC to Alzheimer’s dementia outcomes

Models	Predictors	Outcome: Alzheimer’s dementia Odds ratio (95% CI), p-value
Model 1	LATE-NC	2.22 (1.78, 2.85), p < 0.001
Model 2	Nigral predominant-type LBs	1.64 (0.72, 3.72), p = 0.232
	Limbic-type LBs	1.89 (1.30, 2.74), p < 0.001
	Neocortical-type LBs	3.24 (2.33, 4.51), p < 0.001
Model 3	LATE-NC	2.128 (1.71, 2.77), p < 0.001
	Nigral predominant-type LBs	1.74 (0.75, 4.01), p = 0.189
	Limbic-type LBs	1.91 (1.31, 2.79), p < 0.001
	Neocortical-type LBs	3.07 (2.20, 4.29), p < 0.001

Model 1 has LATE-NC as the independent variable and Alzheimer’s dementia as the outcome. Model 2 has types of LBs as the independent variables and Alzheimer’s dementia as the outcome. Model 3 has LATE-NC and LB-types as independent variables and Alzheimer’s dementia as the outcome. All models were adjusted for age-at-death, sex, education, and AD pathology

ISSN: 2051-5960