Skip to main content

Table 3 Relation of Lewy bodies and LATE-NC pathology to cognitive outcomes

From: The association of Lewy bodies with limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes and their role in cognition and Alzheimer’s dementia in older persons

Models Predictor Outcome
Global cognition Estimate (SE), p-value Episodic memory
Estimate (SE), p-value
Semantic memory
Estimate (SE), p-value
Working memory
Estimate (SE), p-value
Perceptual speed
Estimate (SE), p-value
Visuospatial ability
Estimate (SE), p-value
Model 1 LATE-NC − 0.43 (0.05), p < 0.001 − 0.61 (0.06), p < 0.001 − 0.51 (0.08), p < 0.001 − 0.20 (0.05), p < 0.001 − 0.13 (0.05), p = 0.014 − 0.16 (0.05), p = 0.003
Model 2 Nigral predominant-type LBs − 0.13 (0.19), p = 0.491 − 0.24 (0.22), p = 0.281 − 0.30 (0.27), p = 0.275 0.13 (0.19), p = 0.499 − 0.04 (0.18), p = 0.826 − 0.12 (0.19), p = 0.514
Limbic-type LBs − 0.31 (0.08), p < 0.001 − 0.26 (0.99), p = 0.007 − 0.55 (0.12), p < 0.001 − 0.21 (0.08), p  = 0.013 − 0.15 (0.08), p = 0.060 − 0.11 (0.08), p = 0.169
Neocortical-type LBs -0.60 (0.07), p < 0.001 − 0.56 (0.08), p < 0.001 − 0.79 (0.10), p < 0.001 − 0.49 (0.07), p  < 0.001 − 0.39 (0.07), p < 0.001 − 0.28 (0.07), p < 0.001
Model 3 LATE-NC − 0.40(0.05), p < 0.001 − 0.58 (0.06), p < 0.001 − 0.48 (0.08), p < 0.001 − 0.18 (0.05), p  = 0.001 − 0.10 (0.05), p = 0.052 − 0.15 (0.05), p = 0.007
Nigral predominant-type LBs − 0.15 (0.18), p = 0.421 − 0.27 (0.21), p = 0.215 − 0.32 (0.27), p = 0.233 0.12 (0.19), p  = 0.527 -0.04 (0.18), p = 0.803 − 0.13 (0.19), p = 0.488
Limbic-type LBs − 0.31 (0.08), p < 0.001 − 0.26 (0.09), p = 0.005 − 0.55 (0.12), p < 0.001 − 0.21 (0.08), p  = 0.013 − 0.15 (0.08), p = 0.059 − 0.11 (0.08), p = 0.166
Neocortical-type LBs − 0.56 (0.07), p < 0.001 − 0.49 (0.08), p < 0.001 − 0.74 (0.10), p  < 0.001 − 0.47 (0.07), p  < 0.001 − 0.38 (0.07), p < 0.001 − 0.26 (0.07), p < 0.001
  1. Model 1 has LATE-NC as the independent variable and global cognition or 5 cognitive domains as the outcome. Model 2 has 3 types of LBs as the independent variables and global cognition or 5cognitive domains as the outcome. Model 3 has LATE-NC and LB-types as independent variables and global cognition or 5 cognitive domains as the outcome. All models were adjusted for age-at-death, sex, education, and AD pathology