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Table 3 Relation of Lewy bodies and LATE-NC pathology to cognitive outcomes

From: The association of Lewy bodies with limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes and their role in cognition and Alzheimer’s dementia in older persons

Models

Predictor

Outcome

Global cognition Estimate (SE), p-value

Episodic memory

Estimate (SE), p-value

Semantic memory

Estimate (SE), p-value

Working memory

Estimate (SE), p-value

Perceptual speed

Estimate (SE), p-value

Visuospatial ability

Estimate (SE), p-value

Model 1

LATE-NC

− 0.43 (0.05), p < 0.001

− 0.61 (0.06), p < 0.001

− 0.51 (0.08), p < 0.001

− 0.20 (0.05), p < 0.001

− 0.13 (0.05), p = 0.014

− 0.16 (0.05), p = 0.003

Model 2

Nigral predominant-type LBs

− 0.13 (0.19), p = 0.491

− 0.24 (0.22), p = 0.281

− 0.30 (0.27), p = 0.275

0.13 (0.19), p = 0.499

− 0.04 (0.18), p = 0.826

− 0.12 (0.19), p = 0.514

Limbic-type LBs

− 0.31 (0.08), p < 0.001

− 0.26 (0.99), p = 0.007

− 0.55 (0.12), p < 0.001

− 0.21 (0.08), p  = 0.013

− 0.15 (0.08), p = 0.060

− 0.11 (0.08), p = 0.169

Neocortical-type LBs

-0.60 (0.07), p < 0.001

− 0.56 (0.08), p < 0.001

− 0.79 (0.10), p < 0.001

− 0.49 (0.07), p  < 0.001

− 0.39 (0.07), p < 0.001

− 0.28 (0.07), p < 0.001

Model 3

LATE-NC

− 0.40(0.05), p < 0.001

− 0.58 (0.06), p < 0.001

− 0.48 (0.08), p < 0.001

− 0.18 (0.05), p  = 0.001

− 0.10 (0.05), p = 0.052

− 0.15 (0.05), p = 0.007

Nigral predominant-type LBs

− 0.15 (0.18), p = 0.421

− 0.27 (0.21), p = 0.215

− 0.32 (0.27), p = 0.233

0.12 (0.19), p  = 0.527

-0.04 (0.18), p = 0.803

− 0.13 (0.19), p = 0.488

Limbic-type LBs

− 0.31 (0.08), p < 0.001

− 0.26 (0.09), p = 0.005

− 0.55 (0.12), p < 0.001

− 0.21 (0.08), p  = 0.013

− 0.15 (0.08), p = 0.059

− 0.11 (0.08), p = 0.166

Neocortical-type LBs

− 0.56 (0.07), p < 0.001

− 0.49 (0.08), p < 0.001

− 0.74 (0.10), p  < 0.001

− 0.47 (0.07), p  < 0.001

− 0.38 (0.07), p < 0.001

− 0.26 (0.07), p < 0.001

  1. Model 1 has LATE-NC as the independent variable and global cognition or 5 cognitive domains as the outcome. Model 2 has 3 types of LBs as the independent variables and global cognition or 5cognitive domains as the outcome. Model 3 has LATE-NC and LB-types as independent variables and global cognition or 5 cognitive domains as the outcome. All models were adjusted for age-at-death, sex, education, and AD pathology