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Table 1 Demographics, clinical and neuropathologic characteristics of participants across LATE-NC stages

From: The association of Lewy bodies with limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes and their role in cognition and Alzheimer’s dementia in older persons

Characteristics Total (n = 1,670) LATE-NC Estimate, p-valuea
Stage 0 (n = 805) Stage 1 (n = 307) Stage 2 (n = 167) Stage 3 (n = 391)
Demographics
Age-at-death, mean (SD) yrs 89.55 (6.65) 87.86 (6.95) 89.94 (6.34) 91.39 (5.88) 91.93 (5.52) F3,1666 = 41.32, p < 0.001
Female, n (%) 1146 (68.62) 531 (65.96) 205 (66.78) 116 (69.46) 294 (75.19) χ2 = 11.02, df = 3, p = 0.011
Education, mean (SD) yrs 16.19 (3.60) 16.34 (3.80) 16.21 (3.43) 16.29 (3.62) 15.83 (3.27) F3,1666 = 1.85, p = 0.136
*APOE ε4, n (%) 412 (25.37) 161 (20.64) 65 (21.67) 53 (32.52) 133 (34.91) χ2 = 34.08, df = 3, p < 0.001
Clinical
Global cognitive score; lv, mean (SD) − 1.00 (1.20) − 0.71 (1.11) − 0.87 (1.11) − 1.22 (1.25) − 1.62 (1.20) F3,1660 = 58.89, p < 0.001
Episodic memory; lv, mean (SD) − 0.93 (1.40) − 0.55 (1.28) − 0.76 (1.33) − 1.18 (1.40) − 1.75 (1.33) F3,1659 = 75.60, p < 0.001
Semantic memory; lv, mean (SD) − 1.28 (1.68) − 0.91 (1.45) − 1.15 (1.55) − 1.55 (1.84) − 2.04 (1.88) F3,1663 = 44.85, p < 0.001
Working memory; lv, mean (SD) − 0.75 (1.13) − 0.58 (1.08) − 0.69 (1.07) − 0.91 (1.13) − 1.10 (1.19) F3,1660 = 20.18, p < 0.001
Perceptual speed; lv, mean (SD) − 1.11 (1.06) − 0.95 (1.07) − 1.08 (1.04) − 1.20 (1.01) − 1.43 (1.00) F3,1645 = 18.94, p < 0.001
Visuospatial ability; lv, mean (SD) − 0.57 (1.07) − 0.43 (1.02) − 0.50 (1.10) − 0.69 (1.12) − 0.84 (1.09) F3,1640 = 13.84, p < 0.001
+ Alzheimer’s dementia, n (%) 714 (43.43) 248 (31.47) 119 (39.27) 79 (48.17) 268 (68.89) χ2 = 152.16, df = 3, p < 0.001
Neuropathologic
AD (NIA-Reagan), n (%) 1084 (64.91) 448 (55.65) 205 (66.78) 112 (67.07) 319 (81.59) χ2 = 78.83, df = 3, p < 0.001
AD pathology score, mean (SD) 0.75 (0.60) 0.61 (0.54) 0.76 (0.63) 0.84 (0.68) 1.01 (0.67) F3,1660 = 38.34, p < 0.001
LBs,
n (%)
Nigral predominant type 29 (1.75) 16 (2.01) 6 (1.97) 2 (1.21) 5 (1.28) χ2 = 23.82, df = 9, p = 0.004
Limbic-type 165 (9.88) 72 (9.06) 33 (10.82) 14 (8.48) 46 (11.79)
Neocortical-type 234 (14.14) 86 (10.82) 42 (13.77) 34 (20.61) 72 (18.46)
^HS, n (%) 162 (9.74) 13 (1.62) 10 (3.28) 16 (9.58) 123 (31.54) χ2 = 285.53, df = 3, p < 0.001
  1. aEstimates are either Fdegrees of freedom, observations  values derived from ANOVA tests or chi-square (degrees of freedom)
  2. *Data missing for 46 participants; +data missing for 26 participants; ^data missing for 6 participants
  3. Abbreviations: AD-Alzheimer’s disease;; lv-last evaluation; HS-hippocampal sclerosis; LATE-NC-limbic-predominant age-related TDP-43 encephalopathy neuropathologic change; LBs-Lewy bodies; yrs-years