Fig. 9
From: Loss of presenilin function enhances tau phosphorylation and aggregation in mice
Loss of PS function causes hippocampal-dependent memory deficits in Tau transgenic mice. Morris water maze and CFC was performed with 6 month-old WT, Tau, PS1 cKO;Tau and PS cKO;Tau mice. a Visible platform phase consisted in six trials and platform latency in seconds was measured. b During learning phase, which consisted in six trials during five consecutive days, latency to the platform in seconds was measured. c Latency to the first entry to the target quadrant in seconds, number of crossings to the target quadrant and percentage of time in the target quadrant in the first 30 s of the test were analyzed. d Representative heat map of each analyzed group during the probe test. e CFC showing the percentage of freezing time immediately and 24 h after conditioning. Values represent mean % freezing time ± s.e.m. (n = 7–10 mice/group). Statistical analysis was determined by one or two-way ANOVA followed by Tukey’s post hoc tests. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001