Fig. 7
From: Loss of presenilin function enhances tau phosphorylation and aggregation in mice
MC1 staining reveals aggregated human tau in Tau mice lacking PS1 and both PS. Immunohistochemical images (left) and quantitative analysis (right) of MC1 stained sections in 6 month-old control (WT), Tau, PS1 cKO;Tau and PS cKO;Tau mice. Scale bar: 100 μm. Values represent mean of MC1-positive cells/section ± s.e.m. (n = 3 slices per mouse, 4 mice/group). Statistical analysis was determined by one-way ANOVA followed by Tukey’s post hoc tests. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Abbreviations: Amygdala: basolateral amygdala; CA1/CA3 hippocampus; EC, entorhinal cortex ,