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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Loss of presenilin function enhances tau phosphorylation and aggregation in mice

Fig. 1

Loss of PS causes behavioral abnormalities and age-dependent neurodegeneration in mice. a Clasping and postural alterations in PS cKO mice at 9 months of age. Tail suspension test reveals that PS cKO mice show severe clasping behavior, as observed in PS cKO mice scoring 4 (left image) and 5 (right picture). Quantification graph: Statistical differences in hang tail score in PS cKO mice at 9 months. b Decreased brain size, especially the cortical hemispheres in PS cKO mice. c Age-dependent brain atrophy in PS cKO mice. Total brain (left), cortex (middle) and hippocampus (right) weights are reduced in PS cKO mice during aging (2 to 12 months). Values represent mean ± s.e.m (n = 4–30 mice/group). Statistical analysis was determined by two-way ANOVA followed by Sidak’s post hoc tests. *P < 0.05, ** P < 0.01 and ***P < 0.001 compared to control (WT) mice

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