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Table 1 Demographic characteristics and CSF parameters of healthy controls, CAA patients, and AD patients

From: MFG-E8 (LACTADHERIN): a novel marker associated with cerebral amyloid angiopathy

  Control (n = 37) CAA (n = 23) AD (n = 26) p-Value
Demographics
Age, years, mean ± SD 63.8 ± 8.5 70.6 ± 7.8** 64.3 ± 7.3$ 0.004
Sex (female), n (%) 11 (29.7%) 7 (30.4%) 14 (53.8%) 0.110
CSF parameters, pg/ml
Aβ40, mean ± SD 10,187.9 ± 4009.1 7911.1 ± 3140.1 - 0.032
Aβ42, median (IQR) 895.1 (678–1225) 360 (317.5–462)*** 514.6 (468.6–593.5)***  < 0.001
t-Tau, median (IQR) 231 (170–317) 403 (268–512.5)** 328.6 (183.4–395.3) 0.002
p-Tau, median (IQR) 28 (19–39) 45 (33.5–63.5)** 32.4 (18.1–39.6)$ 0.001
MFG-E8, median (IQR) 4568.4 (3672.3–5898) 3345.5 (2661.8–4648.3)* 5655.6 (4552.6–6849.2)$$$  < 0.001
  1. CAA, Cerebral amyloid angiopathy; AD, Alzheimer’s disease; CSF, cerebrospinal fluid; SD, standard deviation; IQR, interquartile range; -, not known. p-values below 0.05 are shown in bold: *p < 0.05 vs. the control group; **p < 0.01 vs. the control group; ***p < 0.001 vs. the control group; $p < 0.05 vs. the CAA group; $$$ p < 0.001 vs. the CAA group