Fig. 1

Study workflow for the identification of Aβ-associated proteins. a Schematic representation of the LCM proteomic approach for tissue collection, microdissection, data analysis, and protein identification. b Representative brain sections from 24-month-old APP23 and WT mice before and after LCM. I) Aβ plaques from APP23 brains stained with thioflavin S (ThS). II) Aβ-positive vessels from APP23 brains stained with ThS. III) Brain vessels from WT mice stained with tomato lectin (TL). The scale bar indicates 100 μm. c Venn diagram showing the total number of proteins identified in the three experimental groups