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Table 1 Demographic and neuropathological data

From: Anatomic survey of seeding in Alzheimer’s disease brains reveals unexpected patterns

Case f/m age brain wt NFT α-syn TDP-43 APOE Diagnoses
1 f 55 1455 I 0 0  −  ε3/4 intraventricular hemorrhage
2 m 55 1780 I 0 0  −  ε3/3 bronchopneumonia
3 f 50 1293 I 0 0  −  ε3/3 PCOM aneurysm, SAB
4 m 50 1600 I 0 0  −  ε4/4 M. Werlhof, hepatitis C
5 f 72 1070 I 3 0  −  ε3/4 cardiac failure
6 f 79 1165 I 0 0  −  ε3/3 coronary artery disease
7 f 93 1090 III (IV) 2 0  −  na craniocerebral trauma
8 m 68 1380 III 0 0  −  na aspiration pneumonia
9 m 72 1500 III 0 0  −  ε3/4 cardiac failure
10 m 74 1465 III 0 0  −  ε4/4 malignant neoplasm
11 m 76 1520 III 4 0  +  na pneumonia
12 f 81 1130 III 2 0  −  ε3/3 acute myeloid leukemia
13 f 88 1495 III 3 0  −  ε3/4 cerebral hemorrhage parietooccipital
14 m 84 1170 V (VI) 3 0  +  ε3/4 AD
15 f 84 1175 V 3 2  +  ε3/3 AD, ILBD
16 m 58 1335 V 2 0  −  ε3/4 AD, myocardial infarction
17 f 72 1185 V 4 0  −  ε3/3 AD, craniocerebral trauma after falling
18 f 76 1405 V 4 0  −  ε3/4 AD, craniocerebral trauma after falling
19 m 76 1205 V 5 0  −  na AD, cardiac failure
20 m 78 1460 V 5 0  −  ε3/4 AD
Control 21 f 30 1315 0 0 0  −  ε3/3 malignant neoplasm
  1. 20 cases fall into three NFT groups: NFT stage I (4 females, 2 males, 50–79 years); NFT stage III (3 females, 4 males, 68–93 years); NFT stage V (3 females, 4 males, 58–84 years). Abbreviations: f, m—female, male; age—age in years; brain wt—fresh brain weight in grams; NFT—Alzheimer's disease-related neurofibrillary tangle stage using Gallyas silver-iodide staining; —amyloid-β deposition phase using 4G8 IHC; α-syn—Parkinson disease-related neuropathological stage using α-synuclein IHC; TDP-43—43-kDa TAR DNA-binding protein neuronal inclusions; APOEAPOE allele status; n/a -not available; AD—Alzheimer's disease; ILBD—incidental Lewy body disease; PCOM -posterior communicating artery; SAB—subarachnoid bleeding