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Fig. 9 | Acta Neuropathologica Communications

Fig. 9

From: Low-grade peripheral inflammation affects brain pathology in the AppNL-G-Fmouse model of Alzheimer’s disease

Fig. 9

IL-1β stimulation increases Aβ aggregation in primary neuron culture. a Schematic diagram of kinetics of Aβ aggregation in primary neuron after stimulation with IL-1β. b Representative images of different conditions at 0, 12 and 24 h after adding PBS/Aβ1-42HF488 oligomers. The images show an overlay of the color-coded FLIM image and the transmitted image. Scale bar: 20 μm. c Quantification of HF488 fluorescence lifetime of Aβ1-42HF488 oligomers (n = 4). Mean ± SEM, nonparametric Mann–Whitney U test. *p < 0.05

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