Fig. 7

Amyloid β peptide (Aβ and cerebral amyloid angiopathy (CAA) seeding activities of the autopsied patients. Aβ and CAA seeding activities among the Alzheimer’s disease (AD), CAA, AD + CAA, and less Aβ groups (A and B), and correlations between Aβ or CAA seeding activities and A11-positive oligomer ratios or high molecular weight Aβ oligomers ratios (C–F). Aβ and CAA seeding activities in the less Aβ group were significantly higher than those in the other 3 human autopsied patient groups (A and B). In terms of CAA seeding activity, the value in the AD + CAA group was significantly lower than that in the CAA group (B). Aβ and CAA seeding activity was significantly correlated with the A11-positive oligomer ratio (C and D) and the HMW Aβ oligomer ratio (E and F)