Fig. 2

Representative images of the tau pathology of the autopsied human brains. The images of the left medial temporal lobe belong to groups with Alzheimer’s disease (AD) (A and B), cerebral amyloid angiopathy (CAA) (C and D), AD + CAA (E and F), and less amyloid β peptide (Aβ) pathology (G and H). Gallyas-Braak staining (A, C, E, and G) and immunohistochemistry using antibodies against phosphorylated tau (AT8, 1:1,000) as a primary antibody (B, D, F, and H) were performed. In the AD group, many neurofibrillary tangles (NFTs) and neuropil threads with dystrophic neurites were observed (A and B). In the CAA group, only a few pretangles were observed (C and D). In the AD + CAA group, many NFTs, neuropil threads and dystrophic neurites were observed (E and F). In the less Aβ group, many argyrophilic grains with some pretangles were observed (G and H). Scale bar represents 100 µm. AGD: argyrophilic grain disease