Fig. 6

PLX3397 treatment of AD-tau-injected 5XFAD mice led to a trend toward less APP accumulation in plaque-associated processes. a Representative cortical images of NAB228 (Aβ) and 22C11 (APP) IF from control (CTR) and PLX3397-treated (PLX) female 5XFAD mice, with annotation of Aβ plaque-associated APP within the focal plane that were then quantified. b Quantification of Aβ plaque-associated APP signal per plaque. One PLX3397-treated female mouse was excluded from the analysis because brain sections were unavailable at all bregma levels. c Correlation between the mean integrated APP and Aβ signal per plaque for each study mouse shown in B. Circles = controls; Squares = PLX3397-treated. Dashed line represents the 95% confidence limits. Scale bar represents 50 µm