Fig. 4

PLX3397 treatment reduced Aβ plaques and plaque size in layers 4–6 of the cortex. a Representative images of NAB228-positive Aβ IF in cortical layers 4–6 of control (CTR) and PLX3397-treated (PLX) AD-tau-injected 5XFAD mice. Quantification of total Aβ plaque signal in cortical layers 4–6 (b) and area per plaque in layers 4–6 (c). Scale bar represents 0.4 mm