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Table 5 Hippocampal sclerosis (HS) odds ratios for risk variants with and without adjustment for LATE-NC status

From: Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study

Gene MOI SNV Effect Allele LATE-NC Adjusted NACC ROSMAP Meta-Analysis
OR P-value OR P-value OR 95% CI P-value
TMEM106B Additive rs1990622 A Yes 1.23 0.396 1.61 0.017 1.44 (1.07, 1.95) 0.017
No 1.43 0.044 1.55 0.019 1.49 (1.15, 1.91) 0.002
TMEM106B Additive rs7781670 C Yes 1.20 0.456 1.53 0.029 1.39 (1.03, 1.88) 0.030
No 1.47 0.034 1.50 0.028 1.48 (1.15, 1.91) 0.002
GRN Additive rs5848 T Yes 1.37 0.168 1.37 0.123 1.37 (1.02, 1.84) 0.039
No 1.67 0.004 1.43 0.057 1.56 (1.21, 2.00) < 0.001
ABCC9 Additive rs1914361 G Yes 1.92 0.005 1.31 0.152 1.52 (1.14, 2.03) 0.004
No 1.64 0.004 1.35 0.092 1.49 (1.17, 1.90) 0.001
ABCC9 Recessive rs1914361 G Yes 3.87 < 0.001 1.58 0.124 2.23 (1.42, 3.51) < 0.001
No 2.69 < 0.001 1.64 0.075 2.12 (1.45, 3.09) < 0.001
ABCC9 Additive rs704178 G Yes 1.51 0.079 1.52 0.034 1.52 (1.13, 2.04) 0.006
No 1.09 0.618 1.42 0.059 1.23 (0.96, 1.57) 0.099
ABCC9 Recessive rs704178 G Yes 1.77 0.121 1.48 0.171 1.58 (1.02, 2.47) 0.042
No 1.33 0.292 1.43 0.180 1.38 (0.95, 2.01) 0.090
APOE Additive rs769449 A Yes 1.15 0.589 1.54 0.094 1.33 (0.93, 1.90) 0.118
No 1.30 0.188 2.02 0.004 1.54 (1.14, 2.09) 0.005
APOE N/A e4 Carrier N/A Yes 1.74 0.114 1.34 0.318 1.49 (0.96, 2.31) 0.075
No 1.79 0.024 1.91 0.018 1.84 (1.28, 2.66) 0.001
  1. Adjusted effects of single nucleotide variants (SNV) on hippocampal sclerosis (HS). A separate regression model was fit for each variant, mode of inheritance (MOI), and limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) adjustment. All models also adjust for sex, age at death, first three principal components and cohort/study. For rs1990622, rs7781670, and rs704178, the effect alleles are the risk-associated alleles and not the minor alleles. NACC = National Alzheimer's Coordinating Center; ROSMAP = Religious Orders Study and Rush Memory and Aging Project; MOI = mode of inheritance; SNV = single-nucleotide variant; LATE-NC = limbic-predominant age-related TDP-43 encephalopathy neuropathological change; OR = odds ratio; CI = confidence interval.