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Table 4 Adjusted limbic predominant age-related TDP-43 encephalopathy neuropathological changes (LATE-NC) odds ratios for risk variants

From: Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study

Gene MOI SNV Effect Allele NACC ROSMAP Meta-Analysis
OR P-value OR P-value OR 95% CI P-value
TMEM106B Additive rs1990622 A 1.39 0.051 1.08 0.484 1.16 (0.97, 1.39) 0.099
TMEM106B Additive rs7781670 C 1.47 0.024 1.09 0.415 1.19 (1.00, 1.43) 0.057
GRN Additive rs5848 T 1.40 0.042 1.23 0.089 1.29 (1.06, 1.56) 0.010
ABCC9 Additive rs1914361 G 1.16 0.354 1.16 0.171 1.16 (0.97, 1.39) 0.098
ABCC9 Recessive rs1914361 G 0.98 0.933 1.40 0.077 1.25 (0.92, 1.71) 0.151
ABCC9 Additive rs704178 G 0.95 0.764 1.07 0.536 1.03 (0.86, 1.24) 0.732
ABCC9 Recessive rs704178 G 0.80 0.433 1.16 0.394 1.05 (0.78, 1.40) 0.759
APOE Additive rs769449 A 1.70 0.004 2.22 < 0.001 1.95 (1.51, 2.52)  < 0.001
APOE N/A e4 Carrier N/A 1.88 0.010 2.16 < 0.001 2.05 (1.54, 2.74) < 0.001
  1. Adjusted effects of single nucleotide variants (SNV) on limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC). All models adjust for sex, age at death, first three principal components and cohort/study. For rs1990622, rs7781670, and rs704178, the effect alleles are the risk-associated alleles and not the minor alleles. NACC = National Alzheimer's Coordinating Center; ROSMAP = Religious Orders Study and Rush Memory and Aging Project; MOI = mode of inheritance; SNV = single-nucleotide variant; OR = odds ratio; CI = confidence interval.