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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study

Fig. 8

Adjusted odds ratios for hippocampal sclerosis (HS) across variants. Adjusted odds ratio estimates and 95% confidence intervals for genetic single nucleotide variants (SNV) and APOE ε4 carrier status from separate regression models of hippocampal sclerosis (HS) fit using data from the National Alzheimer's Coordinating Center (NACC), the Religious Orders Study and Rush Memory and Aging Project (ROSMAP), and the meta-analysis of NACC and ROSMAP. All regression models were adjusted for sex, age at death, cohort/study, and the first three genetic principal components. Regression models were also adjusted for limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) case status by the including LATE-NC status as an additional predictor variable and these odds ratio estimates are represented by triangles. For each variant, the effect allele is defined as the HS risk-causing allele (HA odds ratio estimates > 1.0), and not necessarily the minor allele. An additive mode of inheritance (MOI) is assumed for all variants except for rs704178 where a dominant MOI was assumed (since a recessive MOI resulted in a significant protective effect for HS). HS = hippocampal sclerosis; LATE-NC = limbic-predominant age-related TDP-43 encephalopathy neuropathological change; NACC = National Alzheimer's Coordinating Center; ROSMAP = Religious Orders Study and Rush Memory and Aging Project

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