Fig. 6

Variant-level results for ABCC9. Adjusted, meta-analytic, single nucleotide variant (SNV)-level p-values for hippocampal sclerosis (HS) and limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) across ABCC9 ± 10 kb assuming a recessive mode of inheritance (MOI). A recessive MOI was assumed for ABCC9 since it has consistently been the MOI with the strongest HS association for ABCC9 [43, 48, 29]. All analyses were for sex, age at death, cohort/study, and the first three genetic principal components. The horizontal dashed line represents the Bonferroni-corrected threshold for significance that accounts for the number of independent tests in the ABCC9 ± 10 kb region. A diamond represents the SNV with the smallest p-value. The previously identified ABCC9 SNV [43] is labeled and identified with an arrow. MOI = mode of inheritance; LATE-NC = limbic-predominant age-related TDP-43 encephalopathy neuropathological change; HS = hippocampal sclerosis