Fig. 4

Variant-level results for TMEM106B and GRN. Adjusted, meta-analytic, single nucleotide variant (SNV)-level p-values for hippocampal sclerosis (HS) and limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) across A. TMEM106B ± 10 kb and B. GRN ± 10 kb. All analyses were adjusted for sex, age at death, cohort/study, and the first three genetic principal components. Horizontal dashed lines represent the Bonferroni-corrected thresholds for significance that account for the number of independent tests in each genomic region. A diamond represents the SNV with the smallest p-value. The previously identified TMEM106B SNV (Rutherford et al. [62]) is labeled and identified with an arrow. MOI = mode of inheritance; LATE-NC = limbic-predominant age-related TDP-43 encephalopathy neuropathological change; HS = hippocampal sclerosis