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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study

Fig. 1

Photomicrographs of human hippocampi depict the main neuropathologic endophenotypes analyzed in the current study. Hippocampal sclerosis (HS) is evaluated with H&E stain (panels A, C, E), whereas LATE-NC is operationalized with phospho-TDP-43 immunohistochemistry (IHC; panels B, D, and F). All photomicrographs depict mid-level hippocampal sections dissected in the coronal plane. Panels A and B show stained brain sections from a woman (APOE e3/e4) who died at age 83; autopsy revealed neither LATE-NC nor HS. Panels C and D are from a man (APOE e3/e4) who died at age 93 with LATE-NC Stage 2. Panels E and F are from a woman (APOE e3/e3) who died at age 95 with LATE-NC Stage 2 and comorbid HS. Note the relatively atrophic hippocampal profile in Panel E in comparison to a or c (same scale bar); the HS + profile in panel E also demonstrates parenchymal rarefaction which can be appreciated even at low magnification. Phospho-TDP-43 immunoreactive intraneuronal inclusions are highlighted with arrows in panels D and F. The representative photomicrographs were from research participants of the University of Kentucky AD Research Center. Scale bar = 2 mm in A, C, and E, 75 microns in A, D, and F

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