Immune cell deconvolution of bulk DNA methylation data reveals an association with methylation class, key somatic alterations, and cell state in glial/glioneuronal tumors

Table 1 Genomic aberrations, Immune cell proportion and tumor subtype in IDH-wt GBM cohort (N = 2072)

Cluster	Major cell Type	Genomic aberrations	Major Subtype
1	Neutrophil	Low CDKN2A/B deletion	GBM-MES
2	Monocyte	EGFR amplification	GBM MES GBM-RTKII
3	Monocyte CD8T	PDGFRA amplification* PTEN deletion MDM2 amplification MYCN amplification EGFR amplification	Mix RTK III
4	Microglia		Mix
5	Monocyte Endothelial B-cell	EGFR amplification* CDKN2A/B deletion* MDM2 amplification*	GBM-RTKII

ISSN: 2051-5960