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Table 1 Genomic aberrations, Immune cell proportion and tumor subtype in IDH-wt GBM cohort (N = 2072)

From: Immune cell deconvolution of bulk DNA methylation data reveals an association with methylation class, key somatic alterations, and cell state in glial/glioneuronal tumors

Cluster Major cell Type Genomic aberrations Major Subtype
1 Neutrophil Low CDKN2A/B deletion GBM-MES
2 Monocyte EGFR amplification GBM MES
GBM-RTKII
3 Monocyte
CD8T
PDGFRA amplification*
PTEN deletion
MDM2 amplification
MYCN amplification
EGFR amplification
Mix
RTK III
4 Microglia   Mix
5 Monocyte
Endothelial
B-cell
EGFR amplification*
CDKN2A/B deletion*
MDM2 amplification*
GBM-RTKII
  1. *Most significant genomic changes as compared to other clusters