Fig. 3

IDH-mutant glioma immune clustering showed two distinct clusters associated with 1p/19q status and different immune cell proportions. a UMAP clustering of three tumor subtypes of IDH-mut tumor cohort (N = 1178) based on immune cell proportion (Non-cancer part scaled from 0 to 1) showed subtype specific clustering. b Two optimum number of cluster obtained in IDH-mut cohort by using k-means clustering with Nbclust method. c Six major Immune cell type proportions shown by boxplots for each cluster indicated significant difference between immune cells distribution between two clusters. Y axis represents non-cancer cell proportion of particular immune cell scaled from 0 to 1. Each box plots depicted, boxes indicate interquartile range with central bar indicating median and whiskers indicating the range. Blue dot represents mean value of the proportion. T-test and Wilcoxon test (p value shown) were used to calculate statistical significance. d Copy number analysis of DNA methylation profile of IDH-mut cohort showed distinct distribution of samples with 1p/19q codeletion