Diffuse leptomeningeal glioneuronal tumour (DLGNT) in children: the emerging role of genomic analysis

Table 1 Molecular profiling of DLGNT cases from the PRISM clinical trial

	Case 1	Case 2
Tumour purity %	71	79
Ploidy	Diploid	Diploid
Tumour mutational burden (mutations/Mb)	0.68 (low)	0.98 (low)
Mutational signatures	NIL	NIL
Somatic mutations	BCOR:c.1555G > T (p.Glu519Ter)	RET:c.2755G > C (p.Ala919Pro)
Fusions	KIAA1549-BRAF	KIAA1549-BRAF
Reportable copy number alterations	1p/19q loss, 1q gain	1p loss, 1q gain, chr8 gain
Germline mutations	NIL	NIL
RNA Expression	Degraded sample	Insufficient sample
Methylation	Match: methylation class diffuse leptomeningeal glioneuronal tumor (0.97)	No match: methylation class family Glioblastoma, IDH wildtype (0.78)

Molecular alterations from WGS, RNAseq and methylome data as curated and discussed at a Multidisciplinary Tumour Board

ISSN: 2051-5960