From: Prion strains associated with iatrogenic CJD in French and UK human growth hormone recipients
Isolate number | Cases | Brain area | ||||
---|---|---|---|---|---|---|
Codon 129 | Origin | Year | Age | Incub period | ||
1 | MM | Fr | 2001 | 31 | 16 | Cort |
2 | Fr | 2006 | 39 | 21 | Cort | |
3 | Fr | 2006 | 36 | 23 | Cort | |
4 | Fr | 2003 | 33 | 20 | Cereb | |
5 | Fr | 2004 | 35 | 21 | Cort | |
6 | UK | 2011 | 46 | 29 | Cort | |
7 | UK | 2012 | 42 | 32 | Cort | |
8 | MV | UK | 2001 | 30 | 20 | Cort |
9 | UK | 1999 | 37 | 19 | Cort | |
10 | Fr | 2006 | 38 | 25 | Cort | |
11 | Fr | 2008 | 27 | 24 | Cereb | |
12 | Fr | 2003 | 35 | 23 | Cereb | |
13 | UK | 1990 | 34 | 17 | Cort | |
14 | VV | UK | 1998 | 27 | 16 | Cort |
15 | UK | 1997 | 36 | 19 | Cort | |
16 | UK | 1995 | 33 | 18 | Cort | |
17 | UK | 1994 | 25 | 11 | Cort | |
18 | Fr | 1991 | 11 | 5 | Cort | |
19 | Fr | 2000 | 27 | 16 | Cort | |
20 | UK | 1993 | 30 | 13 | Cort | |
21 | UK | 1992 | 31 | 16 | Cort | |
22 | Fr | 1999 | 24 | 15 | Cort |
Isolate number | TgMet129 | TgVal129 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Passage 1 | Passage 2 | Passage3 | Passage 1 | Passage 2 | ||||||
Survival time (mean ± SD) | PrPres | Survival time (mean ± SD) | PrPres | Survival time (mean ± SD) | PrPres | Survival time (mean ± SD) | PrPres | Survival time (mean ± SD) | PrPres | |
1 | 585 ± 29 | 1 | 487 ± 34 | 1 | ND | 173 ± 3 | 2 | 171 ± 2 | 2 | |
2 | 582 ± 81 | 1 | 492 ± 57 | 1 | ND | 162 ± 3 | 2 | 179 ± 7 | 2 | |
3 | 569 ± 76 | 1 | > 400* | 163 ± 7 | 2 | 181 ± 11 | 2 | |||
4 | 593 ± 118 | 1 | 298 ± 61 | 1 | 206 ± 9 | 1 | 195 ± 13 | 2 | 165 ± 3 | 2 |
5 | 453 ± 137 | 1 | 204 ± 4 | 1 | ND | 180 ± 6 | 2 | 174 ± 9 | 2 | |
6 | 246 ± 33 | 1 | 213 ± 10 | 1 | ND | 206 ± 6 | 2 | 161 ± 3 | 2 | |
7 | 230 ± 5 | 1 | 193 ± 6 | 1 | ND | 313 ± 5 | 1 | 271 ± 5 | 1 | |
8 | 562 ± 55 | 1 | 456 ± 6 | 1 | ND | 211 ± 12 | 2 | 173 ± 7 | 2 | |
9 | 635 ± 66 | 1 | 503 ± 19 | 1 | ND | 172 ± 10 | 2 | 177 ± 7 | 2 | |
10 | 525 ± 32 | 1 | 488 ± 31 | 1 | ND | 188 ± 15 | 2 | 169 ± 10 | 2 | |
11 | 511 ± 29 | 1 | > 400* | 1 | ND | 164 ± 5 | 2 | 166 ± 9 | 2 | |
12 | 566 ± 170 | 1 | 299 ± 42 | 1 | 194 ± 4 | 1 | 160 ± 10 | 2 | 163 ± 4 | 2 |
13 | 337 ± 66 | 1 | 212 ± 13 | 1 | ND | 193 ± 5 | 2 | 176 ± 15 | 2 | |
14 | 626 ± 57 | 1 | 613 ± 21 | 1 | ND | 176 ± 9 | 2 | ND | 2 | |
15 | 423 ± 23 | 1 | 669 ± 56 | 1 | ND | 180 ± 9 | 2 | 175 ± 5 | 2 | |
16 | 665 ± 15 | 1 | 484 ± 30 | 1 | ND | 165 ± 5 | 2 | 175 ± 14 | 2 | |
17 | 628 ± 83 | 1 | 568 ± 82 | 1 | ND | 198 ± 7 | 2 | 169 ± 7 | 2 | |
18 | 565 ± 19 | 1 | > 400* | 1 | 165 ± 5 | 2 | 180 ± 10 | 2 | ||
19 | 759 ± 64 | 1 | > 400* | 1 | 171 ± 7 | 2 | 177 ± 8 | 2 | ||
20 | 612 ± 122 | 1 | 312 ± 49 | 1 | 202 ± 4 | 1 | 178 ± 7 | 2 | 180 ± 7 | 2 |
21 | 446 ± 165 | 1 | 210 ± 12 | 1 | ND | 194 ± 7 | 2 | 170 ± 3 | 2 | |
22 | 362 ± 48 | 1 | 229 ± 8 | 1 | ND | 439** | 1 | ND |