Fig. 3
From: Prion strains associated with iatrogenic CJD in French and UK human growth hormone recipients
Vacuolar lesion profiles in the brain of human PrP-expressing mice (tgHu) inoculated with human growth hormone iatrogenic CJD cases originating from France and UK. French (Fr) and UK hGH- iCJD isolates were inoculated in transgenic mice that express Met129 (tgMet) or Val129 (tgVal) human PrP (intra-cerebral route, 6 mice, 20µL per mouse). After two iterative passages standardized vacuolar lesion profiles were established in the brains of the mice. Lesion profiles corresponding to M1CJD (○) and V2CJD (●) strains are presented for comparison. Results are presented according to the origin (Fr and UK) and the genotype of patients (homozygous Met129: MM—heterozygous Met129/Val129: MV—homozygous Val129: VV°). Fr MM cases: case 1 (∇), case 2 (∆), case 5 (○). UK MM: case 6 (○), case 7 (∇). Fr MV: case 10 (○), case 12 (∆). UK MV: case 11: case 9 (∇), cases 9 (○), case 13(∆). Fr VV cases: case 18 (∆), case 19 (∇), case 22 (○). UK VV cases: case 14 (○), case 15 (∆), case 22 (∇). For the Fr VV cases 18 and 19, second passage in tgMet were not available at the moment of writing (see Table1)