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Table 1 The changes to basal transmission and LTP measured in different mouse models expressing endogenous mutant, human or wildtype Tau. Results show the large amount of variation dependent upon the method applied, but exogenous oligomeric Tau is consistently impairing LTP

From: Synaptic tau: A pathological or physiological phenomenon?

Study Model and Tau expression Basal transmission LTP
Boekhoorn et al. [37] 9-week Tau-P301L mice. 2 × expression level as compared with endogenous Tau (controlled for in wildtype); Under Thy1 promoter No change Increase
Schindowski et al. [393] G272V and P301S (Thy22) mice. 4–sixfold expression level as compared with endogenous Tau; Under Thy1.2 promoter Reduced No change
Hoover et al. [190] TgP301L mice. 13-fold-expression level as compared with endogenous Tau; Under CaMKII promoter Reduced Impaired induction
Yoshiyama et al. [491] P301S (PS) mice. 3–fivefold expression level as compared with endogenous Tau (controlled for in wildtype); Under mouse prion (MoPrP) promoter Reduced Impaired induction
Polydoro et al. [352] hTau mice. Expression not determined but higher than endogenous levels; Under Tau promoter Reduced Impaired
Koch et al. [236] Human AD patients N/A Impaired. Reversal of LTP toward LTD
Fá et al. [123]
Lasagna-Reeves et al. [251]
Puzzo et al. [360]
Oligomeric exogenous Tau and wildtype mice No change Impaired
Maeda et al. [284] hTau-A152T mice. Three–fivefold expression level as compared with endogenous Tau; Under CaMKII‐tTA promoter Increased No change
Decker et al. [92] hTau- A152T mice Increased No change