Table 1 The changes to basal transmission and LTP measured in different mouse models expressing endogenous mutant, human or wildtype Tau. Results show the large amount of variation dependent upon the method applied, but exogenous oligomeric Tau is consistently impairing LTP
From: Synaptic tau: A pathological or physiological phenomenon?
Study | Model and Tau expression | Basal transmission | LTP |
|---|---|---|---|
Boekhoorn et al. [37] | 9-week Tau-P301L mice. 2 × expression level as compared with endogenous Tau (controlled for in wildtype); Under Thy1 promoter | No change | Increase |
Schindowski et al. [393] | G272V and P301S (Thy22) mice. 4–sixfold expression level as compared with endogenous Tau; Under Thy1.2 promoter | Reduced | No change |
Hoover et al. [190] | TgP301L mice. ∼13-fold-expression level as compared with endogenous Tau; Under CaMKII promoter | Reduced | Impaired induction |
Yoshiyama et al. [491] | P301S (PS) mice. 3–fivefold expression level as compared with endogenous Tau (controlled for in wildtype); Under mouse prion (MoPrP) promoter | Reduced | Impaired induction |
Polydoro et al. [352] | hTau mice. Expression not determined but higher than endogenous levels; Under Tau promoter | Reduced | Impaired |
Koch et al. [236] | Human AD patients | N/A | Impaired. Reversal of LTP toward LTD |
Fá et al. [123] Lasagna-Reeves et al. [251] Puzzo et al. [360] | Oligomeric exogenous Tau and wildtype mice | No change | Impaired |
Maeda et al. [284] | hTau-A152T mice. Three–fivefold expression level as compared with endogenous Tau; Under CaMKII‐tTA promoter | Increased | No change |
Decker et al. [92] | hTau- A152T mice | Increased | No change |