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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Synaptic tau: A pathological or physiological phenomenon?

Fig. 4

A schematic of possible roles of endogenous Tau in synaptic plasticity. The figure shows proteins that have been found to interact with Tau (though not necessarily functionally). Many of these proteins appear to map to clathrin-mediated endocytosis pathways that relate to synaptic vesicle trafficking in the pre-synaptic compartment (a) or receptor trafficking in the post-syanptic compartment (b) and are vital for synaptic transmission. Image based on data from [276]. Tau is not known to directly bind PICK1, GluA2, though there is an NMDA-dependent interaction of this complex with phospho-Tau [370]. These proteins are therefore added to the figure in order to highlight specific pathways that have been previously mentioned in the literature [434]

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