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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Synaptic tau: A pathological or physiological phenomenon?

Fig. 1

Tau is differentially expressed as six isoforms that contain multiple structural domains for diverse protein–protein interactions. a Alternative splicing of exons 2 and 3 (E2, E3) determines the N-terminus region, whereas exon 10 (E10) determines the number of repeat (R) regions and gives rise to 3R or 4R Tau. Overall six isoforms of Tau exist with their expression dependent upon age and anatomical location. b The N-terminus region of Tau is involved in membrane interactions and has been shown to bind to synaptic vesicles [44, 265, 301]. The microtubule binding repeat regions bind and stabilise microtubules [260]

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