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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Importance of extracellular vesicle secretion at the blood–cerebrospinal fluid interface in the pathogenesis of Alzheimer’s disease

Fig. 6

Effect of inhibiting exosome secretion after intracerebroventricular (icv) injection of Aβ oligomers (AβO) on short-term memory (STM) and long-term memory (LTM) (a) Nanoparticle Tracking Analysis (NTA; NanoSight) quantification of the amount of particles in the cerebrospinal fluid (CSF) 6 h after icv injection of scrambled peptide + vehicle (black), AβO + vehicle (grey) or AβO + GW4869 (white) in C57BL/6J mice (n = 5–6). (b) Analysis of the STM in C57BL/6J mice 24 h after injection of either scrambled peptide + vehicle (black), AβO + vehicle (grey) or AβO + GW4869 (white) (n = 16; pooled data of two independent experiments). (c) Analysis of the LTM in C57BL/6J mice 48 h after injection of either scrambled peptide + vehicle (black), AβO + vehicle (grey) or AβO + GW4869 (white) (n = 16; pooled data of two independent experiments)

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