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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Defining tumor-associated vascular heterogeneity in pediatric high-grade and diffuse midline gliomas

Fig. 6

pHGG and DMG endothelial transcriptomes highlight heterogeneity of tumor-associated and normal brain endothelial signaling programs. a Hierarchical clustering of Pearson’s correlation plot visualizing the correlation values between samples. Scale bar represents the range of the correlation coefficients displayed. b Heatmap of the top 25 most significant (adj. p-value) differentially expressed genes between IUE DMG EC and IUE pHGG EC. c Gene sets enriched by over-representation analysis of differentially expressed genes (FC > 4, adj. p < 0.05) between IUE pHGG EC and IUE DMG ECs. d Gene sets enriched by over-representation analysis of differentially expressed genes (FC > 2, adj. p < 0.05) up-regulated in IUE pHGG EC or IUE DMG ECs

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