Fig. 1
From: Defining tumor-associated vascular heterogeneity in pediatric high-grade and diffuse midline gliomas
Tumor associated vascular differences in orthotopic patient derived xenograft pHGG and DMG models. Representative immunofluorescent images of pHGG, DMG PDX samples and normal brain labeled with a hVimentin and Hoechst, b CD31 and c Claudin-5 and Glut1 and Hoechst. Scale bar = 20 μm. Quantification of d CD31-positive blood vessel density in the normal brain (n = 5), DMG PDX (n = 5) and pHGG PDX (n = 3), e branchpoints and f % Glut1-positive blood vessels in DMG PDX (n = 5) and pHGG PDX (n = 3). Data are presented as mean ± SEM *P < 0.05, **p < 0.001, ***p < 0.0001, unpaired t-test with Mann–Whitney posthoc comparison