Fig. 4
DSS colitis induces intestinal inflammation, and loss of RGS10 worsens colitis. A Relative mRNA levels in distal colon tissue from mice given H2O or 2% DSS (5d) followed by water (5d) (n = 5–7 per group (groups distinguished by sex, genotype, and treatment), two-way ANOVA, treatment effect p < 0.05 for all, genotype effect insignificant except for male Lcn2 and Ptprc for which p < 0.05, Tukey’s post hoc). Letter(s) centered above groups reflect results of post hoc tests. Groups that do not share any letter are significantly different from one another. B Disease activity indices of mice with DSS colitis (n = 10–12 per group (groups distinguished by sex, genotype, and treatment), two-way repeated measures ANOVA, genotype effect p = 0.0002 for males and p < 0.0001 for females, Sidak’s post hoc). * indicates significant differences between genotypes each day by post hoc tests