Fig. 10

CD8⁺ T-cell depletion prevents DSS colitis-associated reductions in striatal TH and DAT. From CD8⁺ T-cell-depleted mice given H₂O or DSS followed by saline, A disease activity indices of DSS colitis (n = 7–9 per group (groups distinguished by sex, genotype, and treatment); two-way repeated measures ANOVA, Sidak’s post hoc) and B TH, C ratio of TH phosphorylated at serine 40 to total TH, D DAT, and E VMAT2 in striatum measured by western blot and normalized to total protein (n = 7–9 per group (groups distinguished by sex, genotype, and treatment); two-way ANOVA, genotype effect p = 0.0011 for phosphorylated TH:TH for males, Tukey’s post hoc). Vertical bar indicates blot images are not contiguous. Letter(s) centered above groups reflect results of post hoc tests. Groups that do not share any letter are significantly different from one another