Fig. 8

An expanded suite of disease- and recovery-associated genes in microglia isolated from the rNLS8 cortex. Unsupervised hierarchical clustering of expression values (normalized to row Z-scores) of an expanded suite of 89 disease- and recovery-associated genes in cortical microglia isolated from rNLS8 mice at baseline (control), early disease, late disease and recovery. Clustering used the ward.D method with Euclidean distance. Four discrete gene clusters are identified, where Cluster 1 comprises genes that show elevated expression in early disease relative to control that persists or is further elevated in late disease and recovery, Cluster 2 comprises genes that first show elevated expression in late disease that persists in recovery, Cluster 3 comprises genes with elevated expression specifically during recovery, and Cluster 4 comprises genes that show decreased expression specifically during recovery