Fig. 7

RRWM and survival analysis of the forebrain-cohort and MRI of the cerebellum-cohort. A RRWM of the forebrain-cohort. Long delay probe trials for the old platform position “SE” from day1 to day3, and n = 10–12 per group. B RRWM short delay probe trials for new platform positions. R, reversal session. C The forebrain-cohort was re-tested in MWM at 7-month-old (n = 10–12 per group). D Survival analysis of the forebrain-cohort aged until 600 days old (n = 14–15 per group). E Representative T2-weighted MRI of mid-sagittal brain of the 14-month-old cerebellum-cohort. F Statistical analysis of the cerebellum/brain volume ratio based on the MRI (n = 8 per group). G The cerebellum/brain ratio of other groups relative to Eu controls based on the MRI. Data were represented as mean ± SEM and analyzed by two-way ANOVA and Tukey's multiple comparisons test (A–C), and by Gehan-Breslow-Wilcoxon test (D), and by two-way ANOVA and Tukey's multiple comparisons tests (F–G). See also Additional file 11: Figure S7.