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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Forebrain Shh overexpression improves cognitive function and locomotor hyperactivity in an aneuploid mouse model of Down syndrome and its euploid littermates

Fig. 6

Camk2-hShh but not Pcp2-hShh improves learning and memory in Eu and Ts65Dn. A Escape distance in acquisition trials from training day (TD)1 to 4. B Short (30 min) delay probe trials from TD 1 to 4. C Long delay probe trials. TD2-TD4, 24 h delay probe trials; TD7, 72 h delay probe trials. D The quadrant preference analysis of the 72 h long delay probe trials. Data were represented as mean ± SEM and analyzed by two-way ANOVA and Tukey's multiple comparisons tests. N = 13–16 per group in the forebrain-cohort, and n = 18–21 per group in the cerebellum-cohort. See also Additional file 11: Figure S5 and S6.

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Acta Neuropathologica Communications

ISSN: 2051-5960

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