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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: RIPK1 or RIPK3 deletion prevents progressive neuronal cell death and improves memory function after traumatic brain injury

Fig. 4

RIPK1 and RIPK3 deficiency reduces reactive astrogliosis three months after TBI. a Exemplary GFAP stainings in a wild type (left) and a RIPK1 knockout (right) animal at different distances from the traumatic contusion. Both images show the right hemisphere, but the left image has been mirrored along the midline for better visualization. Scale bar = 20 µm. Significant astrogliosis is present in the WT mouse, while it is heavily reduced in the neuronal RIPK1 deficient mouse. b and c Quantification of astrocyte coverage at different distances from the lesion. Astrocyte coverage was decreased in neuronal RIPK1 (b) and global RIPK3 (c) knockout animals compared to controls. Data are presented as mean ± SD; n = 9–10 for RIPK1, n = 8–9 for RIPK3. Students t-test for parametric and Man-Whitney-Rank-Sum test for non-parametric data were used. *p < 0.05, **p < 0.005, ***p < 0.001

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