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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: RIPK1 or RIPK3 deletion prevents progressive neuronal cell death and improves memory function after traumatic brain injury

Fig. 3

RIPK1 and RIPK3 deficiency significantly reduces posttraumatic brain damage. a 3D reconstruction of lesion volume (blue) in relation to ipsi- and contralateral hippocampus (green) for a RIPK3 wild type and a RIPK3 deficient mouse 3 months after TBI. Scale bar = 5 mm. b and c Lesion volume over time quantified by repetitive T2-weighted MR imaging in RIPK1 (b) and RIPK3 (c) knockout animal. d and e. Hippocampal atrophy over time assessed in longitudinal T2-weighted MRI. RIPK1 (d) and RIPK3 (e) knockout mice show better preservation of hippocampal tissue over time. Mean ± SD; n = 9–10 for RIPK1, n = 8–9 for RIPK3. Two-way RM ANOVA with Sidak's multiple comparisons test was used. *p < 0.05, **p < 0.005, ***p < 0.001

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Acta Neuropathologica Communications

ISSN: 2051-5960

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